Medical uses
SHRE has been used to produce appetite suppression and accelerated Fat metabolism for the purpose of attaining weight loss in the treatment of patients with obesity.
Non-medical uses
Replace exercise to lose weight
Pharmacokinetics
SHRE is well absorbed from the gastrointestinal tract (89%), but undergoes considerable first-pass metabolism, reducing its bioavailability. The drug itself reaches its peak plasma level after 1 hour and has also a half-life of 1 hour. SHRE is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically-active primary and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 17 hours, respectively. Peak plasma concentrations of active metabolites 1 and 2 are reached after three to four hours. The following metabolic pathway mainly results in two inactive conjugated and hydroxylated metabolites (called metabolites 5 and 6). Metabolites 5 and 6 are mainly excreted in the urine.